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Studies on upregulation of amyloid precursor protein in response to traumatic brain injury / Corinna Van Den Heuvel.

by Corinna Van Den Heuvel

Institution: University of Adelaide
Department:
Degree:
Year: 1999
Keywords: Brain Wounds and injuries.; Amyloid beta-protein precursor.
Posted:
Record ID: 1056765
Full text PDF: http://hdl.handle.net/2440/19432


Abstract

Traumatic brain injury (TBI) effects neuronal cell bodies (NCBs), axons and dendrites in a complex fashion, producing a spectrum of damage dependent on the initial injury and secondary effects. Accumulation of amyloid precursor (APP) in NSBs and axons is a feature of TBI. This accumulation may be due to impairment of the axonal transport of APP and/or upregulation of APP mRNA synthesis. This thesis hypothesizes that mechanical deformation, which is not severe enough to cause immediate cell death, results in increased APP mRNA and antigen expression as an acute phase response to injury.

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