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by Corinna Van Den Heuvel
| Institution: | University of Adelaide |
|---|---|
| Department: | |
| Degree: | |
| Year: | 1999 |
| Keywords: | Brain Wounds and injuries.; Amyloid beta-protein precursor. |
| Posted: | |
| Record ID: | 1056765 |
| Full text PDF: | http://hdl.handle.net/2440/19432 |
Traumatic brain injury (TBI) effects neuronal cell bodies (NCBs), axons and dendrites in a complex fashion, producing a spectrum of damage dependent on the initial injury and secondary effects. Accumulation of amyloid precursor (APP) in NSBs and axons is a feature of TBI. This accumulation may be due to impairment of the axonal transport of APP and/or upregulation of APP mRNA synthesis. This thesis hypothesizes that mechanical deformation, which is not severe enough to cause immediate cell death, results in increased APP mRNA and antigen expression as an acute phase response to injury.
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