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Abstracts Biological Sciences
by James Gray Robertson
| Institution: | University of Adelaide |
|---|---|
| Department: | |
| Degree: | |
| Year: | 1999 |
| Keywords: | Insulin-like growth factor-binding proteins.; Wound healing Physiology.; Wounds and injuries Microbiology. |
| Posted: | |
| Record ID: | 1062838 |
| Full text PDF: | http://hdl.handle.net/2440/19703 |
Abstract
Thesis aimed to determine general roles for insulin-like growth factor binding proteins (IGFBPs) in regulating insulin-like growth factor-I (IGF-I) actions in wound repair. Preliminary experiments sought to characterise alterations to IGF-I levels and IGFBP profiles that may occur during wound repair. The effects that interactions with IGFBPs may have on IGF actions in wounds were addressed. Final experiments aimed to determine whether IGFBP-3 proteolysis observed in the initial work of the thesis acted to increase IGF bioavailablity. The results are discussed.
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